Bioanalytical LC-MS Scientist/Senior Scientist
Zoetis

Kalamazoo, Michigan


Zoetis Veterinary Medicine Research and Development (VMRD) seeks an enthusiastic colleague for a challenging and fast-paced position in research and development of veterinary medicines in Kalamazoo, Michigan. The candidate will develop and validate LC-MS/MS bioanalytical methods, and perform bioanalysis in a GLP environment. Additional responsibilities will include method development, validation, and analysis of medicated feeds primarily using HPLC-UV and fluorescence detection. Experience working with Type B/C medicated feed additives and working knowledge of drug stability guidelines is beneficial. The candidate will collaborate extensively with target animal safety, toxicology, pharmacokinetics, environmental, clinical, and regulatory scientists as part of multidisciplinary project teams.

Responsibilities:

• Independent hands-on method development and validation of LC-MS (and HPLC-UV/FL) methods to quantify veterinary therapeutics and/or biomarkers in matrices.

• Analytical subject matter expert and project team representative for VMRD Global Metabolism & Safety.

• Work with project teams, study directors, and regulatory affairs to support or conduct studies within agreed upon timelines.

• Prepare reports and present results to scientific teams and management.

• Participate/lead continuous improvement and innovation efforts within the VMRD Global Metabolism & Safety group.

Basic Qualifications:

• Ph.D. (0 - 2 years of relevant experience), M.S. (with 3+ years of relevant experience), or B.S. (with 5+ years of relevant experience) in chemistry, biochemistry, or related field, with hands-on experience using mass spectrometry techniques to characterize and quantify small and/or large molecule therapeutics and biomarkers.

• Exhibits enthusiasm for analytical chemistry and has a high degree of attention to detail.

• Ability to work effectively as both an individual contributor and in a collaborative team setting.

• Track record of successfully troubleshooting issues that arise during bioanalytical assay development, qualification, validation, and sample analysis.

• Understanding of quality expectations and regulatory guidance around LC-MS therapeutic and biomarker assay development and validation.

• Demonstrated ability to develop, optimize, and validate LC-MS methods for quantitative analysis of analytes in biological matrices (serum, tissue, cell culture).

• Experience with the proper handling and storage of therapeutic and biomarker biological samples and associated critical reagents.

• Excellent written and oral communication skills.

Desired Skill Sets:

• Experience with the operation and maintenance of Sciex (Analyst Software) and Waters (MassLynx) triple quadrupole mass spectrometers.

• Experience with small molecule extraction techniques and basic/advanced large molecule extraction techniques for both biological fluid and tissue matrices.

• Experience with the operation and maintenance of HPLC-UV/FL systems (Waters, Agilent, etc.) and software (Empower, Chromeleon, etc.).

• Experience with laboratory automation for sample extraction workflows. Advanced knowledge of Hamilton Microlab STAR Liquid Handling System and programming (Venus software) is a plus.

• Familiarity with ligand binding assays.

• Experienced with LIMS and PK software, such as Watson, and others.

Full time

Regular

Colleague

Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. We offer reasonable accommodations as an alternative if requested by an individual with a disability. Please contact Zoetis Colleague Services at zoetiscolleagueservices@zoetis.com to request an accommodation. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact. Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of "@zoetis.com". In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.



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