Zoetis Veterinary Medicine Research and Development (VMRD) is looking for a skilled Toxicologist to join the Toxicology group in Global Pharmacokinetics, Dynamics, Metabolism & Safety (GPDMS) based in Kalamazoo, MI, in a challenging and dynamic position that provides technical leadership and expertise in Computational and Genetic toxicology. The candidate will work across the VMRD organization to produce well-researched toxicological risk assessments that justify product safety across therapeutic areas and species, and to support Next Generation Risk Assessment (NGRA).
The responsibilities include:
- In silico and computational toxicology support: Develop and apply In Silico Toxicology (IST) tools such as QSAR and read-across approaches to predict physicochemical and toxicological endpoints and to aid decision-making, especially with regard to mutagenicity prediction
- Conduct mutagenicity prediction for synthetic pathway assessment including the application of Threshold of Toxicological Concern (TTC)
- Apply Integrated Approaches to Testing and Assessment (IATA) tools including New Approach Methodologies (NAM), Adverse outcome pathways (AOP), etc. to fill the gap between evolving scientific research and regulatory assessment challenges
- Aid in the transition to NGRA: including developing new tools and protocols, documentation and integration of in silico toxicology data with non-animal methods, in vitro and in vivo toxicology data
- Develop and apply state-of-the-art in silico assessments to aid toxicology representatives in the selection and optimization of large and small molecule therapeutics
- Contribute to the analysis, integration, visualization, and interpretation of data to contextualize toxicological findings and generate predictive analyses
- Provide scientific expertise in relevant chemistry, toxicology, and computational/ analytical areas
- Preparation of scientific and technical documents such as safety expert reports, regulatory dossier, protocols, technical guidance, position paper, etc.
There is an opportunity for this position to be remote.
- Ph.D. plus at least 5 years of experience in genetic toxicology, medicinal chemistry, computational toxicology, or related scientific discipline. A Master's degree in toxicology with 10 years of experience in the above-mentioned areas will be considered.
- Demonstrated working knowledge of in silico toxicology, medicinal chemistry, genetic toxicology, and NAM fundamentals to evaluate structure-based models and interpret toxicological findings for internal and external regulatory decision making
- Advanced skills in chemical risk assessment tools, toxicology databases, and literature searches
- Excellence in technical writing and communication (regulatory communications, preparing protocols, reports, journal articles, dossiers, etc.)
- Highly organized; Strong interpersonal skills with an ability to develop solid, long-term relationships, influence others, and adept at working across multiple cross-functional areas
- Desirable skills, experience, and attributes:
- Board certification in toxicology
- Knowledge of global regulatory requirements for the preparation of chemical risk assessment
- Experience in conducting studies in a regulated environment (GLP compliance).
- Experience in evaluating the experimental design, and interpretation of studies assessing in vitro and in vivo toxicity and integration of in silico, in vitro, and in vivo data
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Zoetis will consider any candidate for whom an Agency has submitted an unsolicited resume to have been referred by the Agency free of any charges or fees. This includes any Agency that is an approved/engaged vendor but does not have the appropriate approvals to be engaged on a search.
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